Explain the autoregulatory mechanism of GFR.

Question:

Explain the autoregulatory mechanism of GFR.

Answer:

The autoregulation of GFR helps the kidneys maintain a stable filtration rate even when blood pressure changes. This is mainly controlled by the juxtaglomerular apparatus (JGA).

Key Steps

  • When blood pressure drops, JGA releases renin.
  • Renin activates the RAAS (Renin-Angiotensin-Aldosterone System).
  • This causes blood vessels to constrict and raises blood pressure, restoring GFR.
  • When BP rises, the afferent arteriole constricts to reduce GFR back to normal.