Question:
Explain the autoregulatory mechanism of GFR.
Answer:
The autoregulation of GFR helps the kidneys maintain a stable filtration rate even when blood pressure changes. This is mainly controlled by the juxtaglomerular apparatus (JGA).
Key Steps
- When blood pressure drops, JGA releases renin.
- Renin activates the RAAS (Renin-Angiotensin-Aldosterone System).
- This causes blood vessels to constrict and raises blood pressure, restoring GFR.
- When BP rises, the afferent arteriole constricts to reduce GFR back to normal.


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